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CTNS

English name:Technological Centre of Nutrition and Health
Original name:Centre Tecnològic de Nutrició i Salut (CTNS)


Technology Transfer Centre

No No No No Yes No No No No No No



Cami de Valls 81-87
43204 Reus
Spain

Cami de Valls 81-87warning.png"-87" is not declared as a valid unit of measurement for this property.

43204 Reus Catalunya Reus Spain 41° 9' 28" N, 1° 6' 52" E


Website
www.ctns.cat


Related Technology Datasheet

For industry For research organisation For Others
    Technology transfer and dissemination
Consumer, social aspects
Legal aspects
Research funding
Food biochemistry, Omics methodologies, Molecular nutrition (in vitro and in vivo studies), Human nutrition intervention studies, Statistical robustness in the design, execution and analysis of studies
 




Related Facility Datasheet

Technology Application field Equipment available
SCREENING OF BIOACTIVE COMPOUNDS

CHEMOINFORMATICS & BIOCOMPUTATIONAL TOOLS BIOLOGY SYSTEMS

BIOACTIVE INGREDIENTS

FUNCTIONAL FOODS FOOD SUPPLEMENTS NUTRACEUTICALS

Bionformatics tools, specific databases, food-oriented filters (toxicity, ADME, bioavilability, natural sources,...) with 3D-QSAR prediction models


BIOAVAILABILITY OF BIOACTIVE COMPOUNDS BIOACTIVE INGREDIENTS

FUNCTIONAL FOODS FOOD SUPPLEMENTS NUTRACEUTICALS

In vitro co-culture system

Ex vivo digestibility system Human bioavilability metabolomics and foodomics NMR analysis GC-MS Analysis LC-MS/MS and LC-TOF Analysis (also see next)


DESCRIPTION OF BIOLOGICAL PATHWAYS OF BIOACTIVE COMPOUNDS ACTION

EFFICACY OF BIOACTIVE COMPOUNDS

MECHANISM ELUCIDATION

1. Bioactive compounds as a cell signals. -Ligand- Membrane Receptors -Ligand- Nuclear receptors -Ligand- Transcription factors

-Ligand- microRNAs

2. Omics approach 3. Nutritional epigenetics

VALIDATION TOOLS

Omics platforms:

Genomics platform Proteomics platform Metabolomics platform

Equipment: High field NMR 500 Mhz NMR (x2) GC-MS GCxGCTOF LC-MS/MS and LC-TOF Analysis Ultra Sequencer 2D-EF Real-Time RT-PCR with TLDA HD Arrays with hybridation system MALDI-TOF LTQ Orbitrap Velos

In vitro models Cell lines - HepG2, FAO, HEPA, 3T3L1, L6, RAW 264.7,Caco2, HUVEC, INS-1E. -Co-cultures: HepG2 + Caco-2, HepG2 + INS 1-E -PBMC (humans, rat, hamster) Mitochondria -Muscle -Brown adipose tissue

In vivo models -Genetically obese rats and mouse -Mouse, rats and hamster obesity induced by:

  -Cafeteria Diet
  -"High fat" Diet
  -"Moderate high fat" (developed by CTNS)
  -Diabetic rats (streptozotocin)
  -Inflammation induced rats (LPS+IFN-y)


EFFICACY OF BIOACTIVE COMPOUNDS

HUMAN TRIALS

METABOLIC SYNDROME

BONE METABOLISM INTESTINAL HEALTH CVD OTHER PATHOLOGIES

HUMAN TRIALS

Integration of Medicine-Nutrition-Statistic Health Care Primary Assistance Experience on Human Nutrition Trials WEI (Internal Website for online management of trials)

      Online data reports
      Online integration of multicentre trials' human data

Statistical plan in the design, implementation, data processing and writing of final report


Name Function E-Mail Expertise
Francesc Puiggros Scientific Coordinator
Ignasi Papell Project Manager




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Created by LisaMeier on 2 August 2011, at 11:58

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