Software for freeze-drying process design and optimization
- How does it work?
- What can it be used for?
- What can it not be used for?
- Related Facilities
- Further Information
|Key words||Freeze-drying, optimisation, modelling, process design, bacteria preservation, quality|
|Completed by||INRA - IATE, INRA - GMPA|
How does it work?
|Primary objective||Product quality optimization and environmental impact reduction.|
|Working principle|| Freeze-drying (=lyophilisation) is widely used for stabilisation of thermo-sensitive, high added-value products such as pharmaceuticals, proteins, cells, micro-organisms and food. Freeze-drying is a dehydration process in which water and other solvents are removed from a frozen material, through the following steps: freezing, primary drying (sublimation), and secondary drying (desorption). The product is stable at room temperature, conserves its appearance, shape and biological activity, and is easily rehydrated.
Virtual simulation of freeze-drying cycles is needed in order to optimise time-dependent process operating conditions. The simulation software integrates the characteristics of the freeze-drying apparatus, the product to dry and the final expected product quality (3, 4, 6).
|Important process parameters||characteristics of the freeze-drying machine: heat and mass transfer resistances, geometry; these characteristics must be provided to the software.|
|Important product parameters||characteristics of the product to be dried: composition, state diagram, structure of the dried porous layer and expected final quality such as long term stability, preservation of biological activity, etc.|
What can it be used for?
|Operations||Stabilizing, preservation, dehydration|
|Solutions for short comings||
What can it NOT be used for?
|Products||Dry food products|
|Operations||This technology only applies for freeze-drying processes.|
|Other limitations||This technology mainly applies to high added value products.|
|Risks or hazards||Not known|
|Maturity|| Registered software: LyoptM (patented by INRA-GMPA), commercially available.
INRA-GMPA provides expertise to formulate and characterize products, to characterise freeze dryers and to develop freeze-drying cycles, optimised from the point of view of the expected product quality and productivity.
|Modularity /Implementation||This technology is complementary to the existing production lines.|
|Consumer aspects||Perceived product quality is potentially increased (1, 2).|
|Legal aspects|| Registered software: LyoptM (INRA, IDDN.FR.001.100008.000.R.P.2009.000.20700)
Please check local legislation.
|Environmental aspects||Energy savings up to 30% compared to conventional recipes (5).|
Facilities that might be interesting for you
|Institutes||INRA - GMPA, AgroParisTech|
characteristics of the freeze-drying machine: heat and mass transfer resistances, geometry; these characteristics must be provided to the software. characteristics of the product to be dried: composition, state diagram, structure of the dried porous layer and expected final quality such as long term stability, preservation of biological activity, etc. Software and Models 2.1.1 physical stabilizing, other ICT Interviews with researchers from UMR GMPA : Bruno Perret, Christian Tréléa, Isabelle Souchon, Fernanda Fonseca, Stephanie Passot. WikiSysop :Template:Review document :Template:Review status