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Pectin bioactivity

Identification

Key words Pectin, dietary fibre, immunomodulation, anti-cancer agent, bio-based products, detoxification
Latest version 2013/04/08
Completed by KU Leuven LFT

How does it work?

Primary objective Describing the health promoting bioactive properties of pectin and highlighting associated structure – function (bioactivity) relations.
Working principle Pectin is a complex polysaccharide in the cell wall of plants that contains linear as well as branched parts. During food processing and digestion, pectin can undergo several structural changes. The structural properties of pectin are key factors in controling the health-promoting properties of these components. Besides the health benefits of pectin as dietary fibre, pectin has the potential to work against inflammation and cancer and it can bind heavy metals.

As dietary fibre, pectin is reported to prevent cardiovascular diseases by lowering blood cholesterol levels. Furthermore, pectin can limit fat absorption in the body by inhibiting pancreatic lipase activity. Finally, small pectin fragments are reported to enhance immune functions by promoting some prebiotic activities and preventing bacterial adhesion. These health-promoting properties of pectin are mainly attributed to the linear part of the polysaccharide [1,2,3]. Pectin has the potential to work against inflammation by stimulating a series of defensive reactions of the immune system. In case of wounds and oedema, this results in an enhanced healing process. The effect of pectin on the immune system is mostly attributed to the branched regions of pectin [4]. As an anti-cancer agent, pectin can prevent or reduce tumor growth by binding to a protein involved in cancer, i.e. galectin-3. This binding inhibits the ability of galectin-3 to promote the propagation of cancer cells and to prevent cell death. This pectin bioactivity is mainly attributed to branched regions of the polysaccharide [5]. Finally, pectin has been shown to reduce blood levels of heavy metals, thus detoxifying the body. This property is ascribed to some branched regions of pectin [6]. Except for pectin’s prebiotic features, which have been evaluated in vitro, other biological properties of pectin have been assessed on animals and/or humans.

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Additional effects Pectin has been used in the production of bioactive materials. The ability of pectin to form a network in the presence of Ca2+ renders it suitable for the production of apatite, the major bone mineral. Hence, pectin can be used in repairing bone defects [7]. In addition, the Ca2+-crosslinking property of pectin enables the production of materials used in tissue culture and engineering [8]. Finally, pectin can also be used for the production of controlled release matrices for colon specific drug delivery [9].

Pectin structure-bioactivity relations can facilitate strategic process design for pectin-rich materials (fruit/vegetables) in order to achieve selective in situ modification of the polysaccharide. This will enable the production of processed fruit/vegetables with specific bio-functionality.

Important process parameters As pectin is easily reactive, all process parameters (e.g. pH, temperature, pressure, time…) must be carefully controlled in order to achieve targeted modifications.
Important product parameters The structural features of pectin vary with the botanical source. This implies that the production of pectin with definite bioactivity and, thus, specific structural features, requires the choice of appropriate pectin sources.

What can it be used for?

Products Commercial pectin, processed fruits and vegetables, pectin-containing foods
Operations Thermal processing, high-pressure processing, high-pressure homogenisation and/or enzyme technology can be applied to create bioactive pectins.
Solutions for short comings Engineering healthy and functional foods, molecular gastronomy

What can it NOT be used for?

Products Products that do not contain plant-based ingredients
Operations No restricted operations when dealing with pectin-containing food products
Other limitations Some bioactive properties of pectin have not yet been evaluated on human beings. Limited knowledge on human digestion of pectin may prevent accurate interpretation/applications of in vitro studies and animal digestion studies.
Risks or hazards Further processing of engineered foods, such as during handling by consumers (heating, microwaving), can affect the structural features of pectin, thereby altering or destroying the desired bioactivity.

Implementation

Maturity Clinical trials have been made, e.g. [10-11].
Modularity /Implementation Not applicable – current types of food processes can deliver the required structural features for the bioactivity of pectin.
Consumer aspects Consumers preference will be high. Food containing pectin is health-promoting.
Legal aspects Not applicable.
Environmental aspects Not applicable.

Further Information

Institutes University of Alberta AFNS, IFR, Maastricht University Human Biology, UiO Pharmaceutical Chemistry, Heinrich-Heine-University - Institute of Pharmaceutics and Biopharmaceutics, Kyushu Institute of Technology
Companies Nakashima medical
References 1. Brouns, F, Theuwissen, E, Adam, A , Bell, M, Berger, A, Mensink R.P.(2012). Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. European Journal of Clinical Nutrition, 66, 591-599.

2. Hotchkiss, A., Rastall, R., Gibson, G., Eliaz, I., Liu, L.S., Fishman, M.(2009) New bioactive and biobased product applications of pectin. In Schols, H.A., Visser, R.G.F., Voragen, A.G.J., Pectin and Pectinases, (pp 305-312), Netherlands, Wageningen Academic Publishers.

3. Edashige, Y, Murakami, N., Tsujita, T. (2008). Inhibitory effect of pectin from the segment membrane of citrus fruits on lipase activity. Journal of Nutritional Science and Vitaminology, 54, 409-415.

4. Wu, Y., Cui, S.W., Tang, J., Wang, Q., Gu, X. (2007). Preparation, partial characterisation and bioactivity of water-soluble polysaccharides from boat-fruited sterculia seeds. Carbohydrate Polymers, 70, 437-443.

5. Maxwell, E.G., Belshaw, N.J., Waldron, K.W., Morris, V.J. (2011). Pectin – An emerging new bioactive food polysaccharide. Trends in Food Science and Technology, 24, 64-73.

6. Zhao, Z., Liang, L., Fan, X., Yu, Z., Hotchkiss, A.T., Wilk, B.J. Eliaz, I. (2008). The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Alternative therapies, 14, 34-38.

7. Ichibouji, T., Miyazaki, T., Ishida, E., Sugino, A., Ohtsuki, C. (2009). Apatite mineralization abilities and mechanical properties of covalently cross-linked pectin hydrogels. Material Science and Engineering: C, 29, 1765-1769.

8. L, L., Won, Y., Cooke, P., David R. Coffin, Marshal L. Fishman, Hicks, M., Ma, P. (2004). Pectin/poly(lactide-co-glycolide) composite matrices for biomedical applications. Biomaterials, 25, 3201-3210.

9. Sriamornsak, P., Thirawong, N., Puttipipatkhachorn, S. (2005). Emulsion gel beads of calcium pectinate capable of floating on the gastric fluid: effect of some additives, hardening agent or coating on release behavior of metronidazole. European Journal of Pharmaceutical Sciences, 24(4), 363-373.

10. Azémar, M., Hildenbrand, B., Haering, B., Heim, M.E., Unger, C. (2007).Clinical benefit in patients with advanced solid tumors treated with modified citrus pectin: a prospective pilot study. Clinical Medicine Insights: Oncology, 1, 73-80.

11. Guess, B.W., Scholz, M.C., Strum, S.B., Lam, R.Y., Johnson, H.J., Jennrich, R.I. (2003). Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer and Prostatic Diseases, 6(4), 301-304.



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Created by LiesbethV on 8 April 2013, at 13:37